Two different brain networks have been identified in a study linking the location of brain injury to levels of depression in patients after the injury. While one is associated with increased depression symptoms, the other is associated with decreased depression symptoms. The large-scale study led by researchers at the University of Iowa Health Care expands on previous findings and suggests that these brain networks could be potential targets for neuromodulation therapies to treat depression. Neuromodulation therapies, such as transcranial magnetic stimulation or deep brain stimulation, are emerging as new non-pharmacological treatments for mood disorders. However, understanding which parts of the brain to target to get the best therapeutic effect is still limited.